Oncology

The oncology department hub — ten multi-society clinical guideline series covering central venous access in cancer patients, extravasation, cancer-associated thrombosis, febrile neutropenia, CINV, mucositis, hazardous drug handling, cancer pain, immunotherapy adverse events, and survivorship.

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March 2026
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The Clinical Database

Oncology supportive care is the clinical discipline of keeping cancer treatment deliverable and survivable — securing reliable vascular access for months of therapy, preventing and managing treatment toxicities, protecting the clinicians who handle hazardous drugs, and following patients into survivorship. This section of The Clinical Database is the oncology hub: ten evidence-based clinical guideline series covering the supportive care backbone of cancer treatment.

Each series is a multi-society synthesis: recommendations from several authoritative sources — the ASCO central venous catheter care guideline, ASCO/IDSA febrile neutropenia guidance, the INS Infusion Therapy Standards of Practice, and others — are integrated into a single, copyright-free reference with full DOI-linked citations, then split into sequential part pages so each part is individually citable. Every page carries a published date and a lastmod date; prefer lastmod when citing.

For how the series are constructed and maintained, see the Oncology Clinical Guidelines hub.


Guideline Series

Vascular Access & Infusion Safety

SeriesCoversParts
Central Venous Access Devices in OncologyDevice selection and assessment, insertion and site care, maintenance, complications, special populations, quality1 · 2 · 3 · 4 · 5
Chemotherapy ExtravasationVesicant/irritant classification, prevention, recognition, antidote protocols, follow-up, documentation1 · 2 · 3
Cancer-Associated ThrombosisRisk assessment (Khorana), prophylaxis, DOAC/LMWH treatment, special situations, CVAD-related thrombosis1 · 2 · 3 · 4 · 5

The central venous access series is written for the oncology context. For device-level guidance independent of oncology — port access, tunneled catheters, CVC care and removal — see the Central Venous Catheters guide tree in the Vascular Access department.

Supportive Care

SeriesCoversParts
Febrile NeutropeniaRisk stratification (MASCC/CISNE), empiric antibiotics, outpatient management, prophylaxis and G-CSF, antifungals, line infections1 · 2 · 3 · 4
CINV Prevention & ManagementEmetogenic classification, antiemetic pharmacology, regimens by risk tier, assessment and implementation1 · 2 · 3 · 4
Oral & GI MucositisPathobiology and grading, oral mucositis prevention and management, GI and radiation mucositis, HSCT1 · 2 · 3

Safety & Pain Management

SeriesCoversParts
Safe Handling of Hazardous DrugsDrug identification and risk assessment, engineering controls, PPE, spills and waste, surveillance and training1 · 2 · 3 · 4
Cancer Pain ManagementAssessment, analgesic ladder, opioid selection and rotation, adjuvants and interventional approaches, CIPN, special populations1 · 2 · 3 · 4 · 5

Immunotherapy & Survivorship

SeriesCoversParts
Immune Checkpoint Inhibitor Adverse EventsGrade-based irAE management by organ system, corticosteroid protocols, immunosuppressive escalation, rechallenge1 · 2 · 3 · 4 · 5
Oncology Survivorship CareCare plans and surveillance by cancer type, cardio-oncology, late effects, psychosocial health, care models and financial toxicity1 · 2 · 3 · 4 · 5

How to Use This Section

Each series has the same anatomy. The series hub (first column above) carries the clinical framing, a contents table describing what each part covers, and the complete source list with full citations in its footnotes. The part pages carry the substance in reading order, each individually addressable — the antidote protocols for extravasation, the equianalgesic dosing content, the grade-based irAE tables — so a specific part can be bookmarked, cited, or shared on its own.

For protocol and order-set development, start at the series hub: the source list identifies which society documents your institutional standard must reconcile, and the parts show where those sources agree and diverge. For point-of-care reference, deep-link the part page closest to the decision; the part titles above are written to be findable from a search.

The section’s boundaries are deliberate. Device-level vascular access procedure — port access technique, dressing changes, tunneled catheter care — lives in the Vascular Access department, and the oncology series link into it rather than duplicating it. Patient-facing material lives in patient education. Institution-ready policy documents, including antineoplastic therapy administration and hazardous drug management, live in the policy library.


Oncology patients move through every other department on this site; the adjacent hubs carry the connected content:

  • Vascular Access — the device-level foundation: PICCs, implanted ports, tunneled catheters, and the policies and complication guides behind every infusion in this section
  • Emergency Medicine — where febrile neutropenia, irAEs, and treatment complications first present
  • Critical Care (ICU) — sepsis, VTE prophylaxis, and transfusion practice for critically ill cancer patients
  • Infection Prevention — the cross-department hub for CLABSI prevention and infection control, directly relevant to neutropenic patients with central lines

Frequently asked questions

What does the oncology section of The Clinical Database cover?
Ten evidence-based clinical guideline series for oncology practice: central venous access devices in cancer patients, chemotherapy extravasation, cancer-associated thrombosis, febrile neutropenia, CINV prevention, oral and GI mucositis, safe handling of hazardous drugs, cancer pain management, immune checkpoint inhibitor adverse events, and survivorship care. Each series is a multi-part synthesis of professional-society recommendations with DOI-linked citations.
How are these oncology guidelines built?
Each series synthesizes recommendations from multiple authoritative sources — for example, the central venous access series draws on the ASCO central venous catheter care guideline and the INS Infusion Therapy Standards of Practice, and the febrile neutropenia series draws on ASCO/IDSA guidance — into a single copyright-free reference with full DOI-linked citations, split into sequential part pages. Every page carries a published date and a lastmod date.
Why does oncology have its own vascular access series?
Cancer patients carry distinct vascular access risks: long treatment courses, vesicant chemotherapy, thrombocytopenia and neutropenia during nadir, and elevated catheter-related thrombosis risk. The Central Venous Access Devices in Oncology series addresses device selection, insertion, maintenance, and complications in that context. For device-level guidance independent of oncology — port access technique, tunneled catheter care, CVC removal — see the Central Venous Catheters guide tree in the Vascular Access department.
Are these guidelines a substitute for institutional protocols?
No. They are reference syntheses of published professional-society recommendations, intended to support clinicians and inform institutional protocol development. Local protocols, treatment plans, and medical direction govern actual care.

Oncology Clinical Guidelines

Comprehensive, evidence-based clinical guidelines for oncology practice — synthesized from multiple professional society recommendations covering vascular access, supportive care, safety, pain management, immunotherapy, and survivorship.